Curcumin, which is the main active ingredient of Tumeric, has powerful anti-inflammatory properties that promote soothing comfort in muscles and joints by blocking the COX-2 enzymes responsible for inflammation and pain. In addition, curcumin also boosts the activity of your body’s antioxidant enzymes. In that way, curcumin delivers a one-two punch against free radicals, blocking them directly and then stimulating antioxidant defenses.
L-Arginine is an amino acid that can improve blood flow and clear out inflammation in the body. The antioxidant supplementation of L-Arginine restores the balance between reactive oxygen species and antioxidants, thereby protecting tissues from the harmful effects of oxidative stress.
It’s no secret that matcha green tea leaf powder has amazing antioxidative properties. Studies have shown that when matcha green tea is used in addition to a balanced diet, it can improve the overall antioxidative status and protect against oxidative damage within the body.
Choline has been shown to reduce inflammation in the body. A clinical study published in the American Journal of Clinical Nutrition showed that study participants who had higher levels of choline had lower levels of inflammation markers, such as C-reactive protein or CRP, in their blood.
Japanese Knotweed (Polygonum cuspidatum Extract (root) 98% resveratrol) is a rich source of antioxidant agents that also provide anti-inflammatory potential. It helps prevent oxidative stress and improves cellular integrity. In the case of inflammation, studies reported that grape seed extract suppresses the release and expression of pro-inflammatory cytokines (IL-6, IL-8, IL-1β and tumor necrosis factor-alpha, etc.) responsible for inflammation progression or development [65]. Moreover, it modulates gut microbiota, improves gut immune response, and supports optimal gut microbiota. These gut health benefits may help the management of inflammatory conditions in the gastrointestinal tract. Additionally, grape seed extract supplementation increases the expression of anti-inflammatory cytokines such as interleukin-10 and transforming growth factor-beta-1, helping suppress inflammation.
Panax ginseng, well known for its medicinal properties, regulates each type of immune cell including, macrophages, natural killer cells, dendritic cells, T cells, and B cells. Ginseng can alleviate pathological symptoms and prevent potential diseases thanks to its anti-inflammatory, antioxidant, and homeostatic properties, as well as have other positive effects on your biological metabolism.
GABA (Gamma-Aminobutyric Acid) is an inhibitory neurotransmitter in the nervous system that suppresses the sensation of pain and anxiety. It is the most prevalent inhibitory neurotransmitter with high concentrations in the brain and spinal cord and is present in 60-70% of all synapses in the central nervous system. GABA plays an important role in sensitivity for neuronal firing, mood, cognition, pain, sleep, and movement disorders.
Boswellia and its active ingredients, such as boswellic acid, have a good anti-inflammatory effect on the body. One of these acids, boswellic acids, acetyl-11-keto-β-boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation. Modern medicine and pharmacology strongly point out to its use as an antiarthritic, anti-inflammatory, anti-hyperlipidemic (controls blood lipids), anti-atherosclerotic (anticoronary plaque), analgesic (pain-reliever) and it being hepatoprotective (protects the liver).
5-Hydroxytryptophan, or 5-HTP for short, suppresses inflammation and arthritic pain by decreasing the production of pro-inflammatory mediators. It’s an amino acid, meaning it builds muscles, causes chemical reactions in the body, transports nutrients, prevents illness, and carries out other functions. We chose to formulate Varvimax™ using 5-HTP because it is the amino acid that metabolizes into serotonin, a neurotransmitter that controls mood and pain.
Glutamine, an amino acid, is an abundant constituent of proteins. It is the only amino acid capable of readily crossing the blood/brain barrier and, with glutamic acid, is thought to account for about 80 percent of the amino nitrogen of brain tissue.
Serine is an amino acid that plays a crucial role in the body’s metabolic processes. A study published in the journal Cell Metabolism found that serine can be used to control inflammation by modulating levels of a protein known as IL-1ß. The study showed that when macrophage cells were deprived of serine, their glutathione levels decreased, which in turn decreased levels of IL-1ß. This suggests that serine can control inflammation by regulating the production of IL-1ß.
Piperine is added to enhance the bioavailability of curcumin and other ingredients for optimal therapeutic properties against chronic pain and inflammation. Studies also showed the anti-inflammatory effect of piperine isolated from black pepper through inhibiting enzymes (COX-2) and inflammatory cytokines (TNF-α and Interleukins-6) involved in the inflammatory cascade.
Vitamin B6, also known as pyridoxine, belongs to the vitamin B family and is important for metabolism, immune response, neurotransmission, and other physiological functions. Studies on vitamin B6 revealed significant anti-inflammatory and analgesic potential in the management of various chronic medical conditions. It effectively inhibits the pro-inflammatory cytokines (TNF-α, interleukins) and also suppresses the enzymatic activity of inflammatory enzymes such as COX-2 and iNOs responsible for inflammatory cascade.
Astaxanthin has been shown to reduce inflammation by acting on reactive oxygen species to reduce proteins that can cause inflammatory diseases like celiac disease, rheumatoid arthritis, heart disease, and diabetes. Astaxanthin also supports joint and muscle health, promotes heart health, supports cognitive function, and improves immune function.
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is found in high concentrations in the brain and retina. DHA is known to have several health benefits, including reducing inflammation and pain. A study published in the journal Nutrients found that DHA can help reduce inflammation by modulating the production of cytokines, which are proteins that play a key role in the immune response.
Another study published in the same journal found that DHA can help reduce the symptoms of rheumatoid arthritis, a chronic inflammatory disorder that causes joint pain and swelling. DHA has also been shown to reduce the risk of heart disease by lowering triglyceride levels and improving cholesterol profiles.
Eicosapentaenoic acid (EPA) is an omega-3 fatty acid that is found in cold-water fish and seafood. EPA has been shown to reduce inflammation by modulating the production of cytokines, which are proteins that play a key role in the immune response. A study published in the Proceedings of the National Academy of Sciences found that EPA can reduce both neuropathic and inflammatory pain by inhibiting an important signaling molecule called vesicular nucleotide transporter.
Another study published in the journal Nutrients found that higher intakes of omega-3 PUFAs, especially EPA and docosahexaenoic acid (DHA), are associated with a lower incidence of chronic diseases characterized by elevated inflammation, including cardiovascular diseases.
RA is one of the most common forms of inflammatory arthritis. It typically affects joints in the hands, wrists, and knees.
PsA is a chronic (long-lasting) form of arthritis that typically occurs in people with psoriasis—an autoimmune condition that speeds up the growth of skin cells. Roughly 30% of people with psoriasis develop PsA.
There has been an evolution of thought about whether inflammation is what causes osteoarthritis. And research is now showing that it is thought to be an inflammatory disease. Inflammation (swelling, pain, and warmth) of a synovial membrane, which is a layer of connective tissue that lines a joint, such as the hip, knee, ankle, or shoulder. Synovitis is caused by some types of arthritis and other diseases.
AS is a chronic form of arthritis that causes inflammation of the spine and sacroiliac joints (where the spine connects with the pelvis). It can also affect the hips and knees.
SLE is the most common type of lupus—up to 70% of people with lupus have it. SLE causes inflammation in multiple organs and systems in the body. It can affect the heart, lungs, kidneys, and brain. Often referred to as simply "lupus."
Gout, a painful and potentially debilitating form of inflammatory arthritis, develops when tiny, needle-shaped crystals of uric acid (a biological waste product) accumulate in the joints.
The role of inflammation in fibromyalgia has been the topic of debate for decades. Fibromyalgia is frequently referred to as an arthritis-related condition. In recent years, multiple studies have revealed several markers of inflammation in people with fibromyalgia, including high levels of C-reactive protein and pro-inflammatory cytokines.
Frequently Asked Questions
VARVIMAX™ consists of essential amino acids and flavonoids that are not commonly found in a regular diet. VARVIMAX™ contains high levels of anthocyanins, which have been shown to possess anti-inflammatory and antioxidant properties. The use of VARVIMAX™ capsules has been developed to restore and maintain the balance of neurotransmitters in the body to alleviate chronic pain, fatigue, and inflammatory conditions. The formulation includes amino acids and flavonoids such as choline L-bitartrate, GABA, L-arginine, black pepper (piperine), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), trans-resveratrol 98% (polygonum cuspidatum extract), which all have anti-inflammatory effects and play a significant role in pain management. Studies have shown that these ingredients have been effective in reducing pain, and inflammation and improving joint function in patients with arthritis, fibromyalgia, and other inflammatory conditions. The most common side effects reported were gastrointestinal symptoms, such as nausea and diarrhea. The current review is conducted to evaluate the safety and efficacy of VARVIMAX™ composition for the management of chronic pains in conditions like Arthritis and Fibromyalgia.
Medical Foods work through a different pathway from prescription pharmaceuticals and do not interfere with prescription medications. In fact, we recommend it be used as an adjunct to patients’ existing treatment/therapy. The nutritional management of disease states allows physicians additional flexibility in the use of pharmaceutical agents. However, as in all situations, please check with your physician about using and how to use Varvimax™
YES! VARVIMAX™ is covered by most payers including private insurance and Medicaid plans. Medicare does not cover oral products for medical foods. VARVIMAX™ billing HCPCS code is S9432 or B9998. We have an insurance specialist on staff, through Enteral Hearts LLC, free of charge, to help those using VARVIMAX™ navigate with the insurance and approval process. We will actually all the work to get the 3 rd Party Insurance approve Varvimax™ for the patient. Simply follow the instructions in our site, entitled “How to Order Varvimax™ Medical Food and
Reimbursement Requirements”.
Orders placed before 12PM EST usually ship the same business day. Orders placed after 12:00PM EST will usually ship the next business day.
Most orders are received within 72 hours from the time your order is shipped.
Our standard shipment modality is Free of Charge within the contiguous United States only. An extra charge is applied to orders to Alaska, Hawaii, Puerto Rico, U.S. Virgin Islands. But, we will inform you prior to shipping product.
We do not deliver to PO Box addresses.
Yes, for a charge. Free shipping offer does not apply if using next-day early or Saturday shipping services.
Tracking numbers and any backorder details will be sent to the e-mail address (provided by you during registration) within 24 hours of shipment. If for some reason you did not receive the status at your e-mail address, please make sure that the e-mail address provided is correct and that you are not using a spam-blocking service. If you are using a spam blocking service, please make sure to add info@lanfam-med.com to a safe list, so that you may receive your order confirmations, order status and tracking information.
No. At this time, we do not ship international orders.
Returns are accepted for damaged product or product sent in error. Any damage or errors with your shipment must be reported immediately. Damages, short shipments and any errors must be reported within 5 business days for credit to be issued or replacement products to be sent. Returns must be pre-approved. No product will be accepted for credit or replacement without prior approval and a Returns Authorization. Please email Lanfam LLC at info@lanfam-med.com with the following information to receive a Return Authorization Number (RA):
1. Product name
2. Reason for return
3. Lot number
4. Date of expiration
Credit will be issued upon receipt and inspection of returned product.
We have included under “Medical Reimbursement” what the Health Care Provider must supply in order to obtain 3rd Party Reimbursement.
As a designated Medical Food, FDA-approval does not apply. However, all ingredients in our patented formula are listed in the FDA Generally Recognized as Safe (GRAS) Food Substances, and our facility is compliant with Current Good Manufacturing Practices.
There have been numerous clinical trials using the ingredients in Varvimax™ and there have been no reports of any serious side effects, even in much higher doses than we are using. The most common side effects reported were typical gastrointestinal symptoms, such as nausea and diarrhea.
Each person is different, and it may take longer for Varvimax™ to reach its full potential in your system. Although we have seen a great success rate with Varvimax™, it does not work for everyone. For the best chance of success, we recommend staying on Varvimax™ for at least 1 to 2 months.
Each bottle is stamped with an expiry date and lot number. From manufacture, Varvimax™ has 24 months dating.
We proudly manufacture each bottle in the USA. We feel most comfortable manufacturing Varvimax™ in our country, which assures us of the highest standards of production. Furthermore, we are proud to say, “MADE IN USA”!
© 2024 VARVIMAX™
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Frequently Asked Questions
VARVIMAX™ consists of essential amino acids and flavonoids that are not commonly found in a regular diet. VARVIMAX™ contains high levels of anthocyanins, which have been shown to possess anti-inflammatory and antioxidant properties. The use of VARVIMAX™ capsules has been developed to restore and maintain the balance of neurotransmitters in the body to alleviate chronic pain, fatigue, and inflammatory conditions. The formulation includes amino acids and flavonoids such as choline L-bitartrate, GABA, L-arginine, black pepper (piperine), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), trans-resveratrol 98% (polygonum cuspidatum extract), which all have anti-inflammatory effects and play a significant role in pain management. Studies have shown that these ingredients have been effective in reducing pain, and inflammation, and improving joint function in patients with arthritis, fibromyalgia, and other inflammatory conditions. The most common side effects reported were gastrointestinal symptoms, such as nausea and diarrhea. The current review is conducted to evaluate the safety and efficacy of VARVIMAX™ composition for the management of chronic pains in conditions like Arthritis and Fibromyalgia.
Medical Foods work through a different pathway from other prescription pharmaceuticals and do not interfere with prescription medications. In fact, we recommend it be used in adjunct to patients’ existing treatment/therapy. The nutritional management of disease states allows physicians additional flexibility in the use of pharmaceutical agents. However, as in all situations, please check with your physician about using Varvimax™.
YES! VARVIMAX™ is covered by most payers including private insurance and Medicaid plans. Medicare does not cover oral products for medical foods. VARVIMAX™ billing HCPCS code is S9432 or B9998. We have an insurance specialist on staff, through Enteral Hearts LLC, free of charge, to help those using VARVIMAX™ navigate with the insurance and approval process. We will actually all the work to get the 3 rd Party Insurance approve Varvimax™ for the patient. Simply follow the instructions in our site, entitled “How to Order Varvimax™ Medical Food and
Reimbursement Requirements”.
Orders placed before 12PM EST usually ship the same business day. Orders placed after 12:00PM EST will usually ship the next business day.
Most orders are received within 72 hours from the time your order is shipped.
Our standard shipment modality is Free of Charge within the contiguous United States only. An extra charge is applied to orders to Alaska, Hawaii, Puerto Rico, U.S. Virgin Islands. But, we will inform you prior to shipping product. We do not deliver to PO Box addresses.
Tracking numbers and any backorder details will be sent to the e-mail address (provided by you during registration) within 24 hours of shipment. If for some reason you did not receive the status at your e-mail address, please make sure that the e-mail address provided is correct and that you are not using a spam-blocking service. If you are using a spam blocking service, please make sure to add sales@lanfam-med.com to a safe list, so that you may receive your order confirmations, order status and tracking information.
No. At this time, we do not ship international orders.
Returns are accepted for damaged product or product sent in error. Any damage or errors with your shipment must be reported immediately. Damages, short shipments and any errors must be reported within 5 business days for credit to be issued or replacement products to be sent. Returns must be pre-approved. No product will be accepted for credit or replacement without prior approval and a Returns Authorization. Please email Lanfam LLC at sales@lanfam-med.com with the following information to receive a Return Authorization Number (RA):
1. Product name
2. Reason for return
3. Lot number
4. Date of expiration
Credit will be issued upon receipt and inspection of returned product.
Please refer to the enrollment forms for this information.
